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Scientists analyzed research that examined how titanium dioxide nanoparticles interact with the brain for a 2015 review published in Nanoscale Research Letters. The researchers wrote: “Once the TiO2 NPs are translocated into the central nervous system through [certain] pathways, they may accumulate in the brain regions. For their slow elimination rates, those NPs could remain in the brain zones for a long period, and the Ti contents would gradually increase with repeated exposure.” After reviewing dozens of studies, the scientists concluded: “Long-term or chronic exposure to TiO2 nanoparticles could potentially lead to the gradually increased Ti contents in the brain, which may eventually induce impairments on the neurons and glial cells and lead to CNS dysfunction as a consequence.”

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Raw material costs, particularly the price of titanium ore, have a significant impact on the price of titanium dioxide. As the cost of titanium ore rises, manufacturers may pass on these increased costs to consumers, leading to higher prices for titanium dioxide. Additionally, production capacity can also affect the price per ton. When there is excess capacity, manufacturers may compete for market share by lowering prices, which can lead to lower prices for consumers.

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